RASopathic Skin Eruptions During Vemurafenib Therapy
March 2013
in “
PLoS ONE
”
vemurafenib V600 mutant BRAF inhibitor photosensitivity maculopapular exanthema pruritus folliculitis alopecia keratosis pilaris acanthopapilloma plantar hyperkeratosis keratoacanthoma squamous cell carcinoma melanoma UVA protection skin reactions itching hair loss skin thickening skin cancer sun protection
TLDR Vemurafenib causes skin side effects similar to RASopathies, requiring regular skin checks and UVA protection.
The document discussed the occurrence of RASopathic skin eruptions in 28 patients undergoing Vemurafenib therapy for metastatic melanoma. 93% of patients experienced skin reactions, including photosensitivity (57%), maculopapular exanthema (50%), pruritus (29%), folliculitis (18%), and hair thinning (29%). The study highlighted the need for awareness and management of these side effects, emphasizing regular dermatological assessments and UVA protection. It also suggested that combining Vemurafenib with MEK inhibitors might reduce skin lesions, warranting further investigation.
