RASopathic Skin Eruptions During Vemurafenib Therapy
March 2013
in “
PLoS ONE
”
vemurafenib V600 mutant BRAF inhibitor photosensitivity maculopapular exanthema pruritus folliculitis alopecia keratosis pilaris acanthopapilloma plantar hyperkeratosis keratoacanthoma squamous cell carcinoma melanoma UVA protection skin reactions itching hair loss skin thickening skin cancer sun protection
TLDR Vemurafenib causes skin side effects similar to RASopathies, requiring regular skin checks and UVA protection.
Vemurafenib, a V600 mutant BRAF inhibitor, was studied for its cutaneous side effects in 28 patients with advanced melanoma. The study found that 93% of patients experienced skin reactions, including photosensitivity, maculopapular exanthema, pruritus, folliculitis, mild alopecia, and nail changes. Common skin reactions included keratosis pilaris, acanthopapilloma, plantar hyperkeratosis, keratoacanthoma, and invasive squamous cell carcinoma. One patient developed a second primary melanoma. The study concluded that Vemurafenib's skin side effects resemble those of RASopathies and emphasized the need for regular dermatological assessments and UVA protection.
