Lesions in the Skin, Intestine, and Central Nervous System Induced by an Antimetabolite of Niacin

    February 1986 in “ PubMed ”
    H. Aikawa, Kinuko Suzuki
    TLDR Injecting newborn mice with a niacin blocker caused skin, gut, and brain damage similar to human pellagra.
    In 1986, a study was conducted on newborn mice to understand the effects of 6-aminonicotinamide (6-AN), an antagonist of niacin, which is known to cause pellagra in humans. Pellagra is characterized by dermatitis, diarrhea, and dementia. The mice were given a single intraperitoneal injection of 6-AN (50 mg/kg body weight) and developed lesions in the skin, intestinal tract, and central nervous system. Notably, there was a delay in hair growth, with the first microscopic abnormality being a vacuolar change in the hair follicles on post-injection Day 3. By Day 5, hyperkeratosis and irregular acanthosis were observed. In the central nervous system, neuronal chromatolysis was observed in anterior horn cells in the spinal cord and motor neurons in the brain. While the pathologic features of these 6-AN-treated mice may not be exactly identical to those of human pellagra, the study suggested that this experimental model could help elucidate possible mechanisms in the development of pellagra lesions.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 6 month progress on min & fin, stay consistent

      in Progress Pictures  455 upvotes 2 days ago
      The conversation is about a user's 6-month progress using topical Minoxidil (5%) and oral Finasteride (2.5 mg) for hair loss, emphasizing consistency for results. The user reports some side effects like mental fog and increased body hair but no significant changes in libido.

      community 6 Month Finasteride only Results

      in Progress Pictures  133 upvotes 1 week ago
      A user shared their 6-month progress using finasteride for hair loss, reporting significant improvement without side effects. They previously used saw palmetto and currently take omega-3, curcumin, and vitamin D supplements.

      community 6 Months (July-December). Fin + Min.

      in Progress Pictures  380 upvotes 2 weeks ago
      The user experienced significant hair regrowth in six months using 1.25mg oral finasteride and topical Kirkland minoxidil once a day. Others suggested additional treatments like dermastamping and alternative products, while some noted varying responses and potential side effects.

      community 6 months journey. Minoxidil, fin, ketaconazole and dermaroller

      in Progress Pictures  32 upvotes 1 month ago
      A user shared their 6-month hair loss treatment journey using minoxidil, finasteride, ketoconazole, and a dermaroller, noting minimal changes between months 3 and 6. Other users discussed similar routines, cutting finasteride pills, and the benefits of using a dermastamp over a roller.

    Related Research

    1 / 1 results