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GlossaryPellagra

disease from niacin deficiency causing dermatitis, diarrhea, dementia

Pellagra is a disease caused by a deficiency of niacin (vitamin B3) or its precursor tryptophan. It is characterized by the "three Ds": dermatitis, diarrhea, and dementia, and if left untreated, it can be fatal. This condition often arises in populations with diets heavily reliant on corn, which lacks adequate niacin and tryptophan unless properly processed.

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research Pellagra and Anorexia Nervosa: A Case Report

8 citations, September 2019 in “Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity”

A woman with anorexia nervosa improved after treatment for pellagra, reminding doctors to check for this deficiency in patients with eating disorders.

research The Photosensitive Patient: Could It Be Pellagra?

2 citations, May 2011 in “British Journal of Dermatology”

Pellagra, caused by niacin deficiency and presenting with photosensitivity, should be considered in patients with relevant symptoms and risk factors.

research The Nutritional Approach to Experimental Dermatology: Nutritional Dermatoses in the Rat

22 citations, August 1940 in “The journal of investigative dermatology/Journal of investigative dermatology”

Rats with a pellagra-like skin condition were cured by a vitamin found in yeast, later identified as vitamin B6.

research Lesions in the Skin, Intestine, and Central Nervous System Induced by an Antimetabolite of Niacin

12 citations, February 1986 in “PubMed”

Injecting newborn mice with a niacin blocker caused skin, gut, and brain damage similar to human pellagra.

research Cutaneous Manifestations of Eating Disorders

48 citations, July 2002 in “Journal of Cutaneous Medicine and Surgery”

Skin problems are common and important signs of eating disorders and treating the eating disorder can improve these skin conditions.

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