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research Epigenetic Mechanisms, Assessment and Therapeutics of Epidermal Stem Cells in Skin Aging

January 2025 in “Stem Cells International”

This review discusses the role of epigenetic modifications in the aging of epidermal stem cells (EpSCs), highlighting mechanisms such as DNA methylation, histone modifications, and noncoding RNA. These modifications are crucial in regulating EpSC function and their dysregulation contributes to aging. The review also introduces epigenetic clocks like Horvath's and VisAgeX, which serve as biomarkers for biological age and help assess aging progression and therapeutic outcomes. Emerging interventions targeting these epigenetic disruptions show promise for antiaging treatments and innovative dermatological therapies.

research Epigenetic Age Estimation in Saliva and Buccal Cells

19 citations , August 2022 in “Forensic Science International Genetics”

The model accurately predicts age from saliva and buccal cells for forensic use.

research The Microanatomy of Human Skin in Aging

5 citations , April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Aging skin shows thinner layers, fewer hair follicles, and new biomarkers like increased space between cells and smaller sebaceous glands.

research A State-Of-The-Art Overview On (Epi)Genomics And Personalized Skin Rejuvenating Strategies

December 2025 in “Pharmaceutics”

Personalized skin rejuvenation using genomics shows promise but needs more research.

research Recent Advances in Forensic DNA Phenotyping of Appearance, Ancestry, and Age

89 citations , April 2023 in “Forensic Science International Genetics”

Forensic DNA Phenotyping can now better predict appearance, ancestry, and age from DNA, but more research is needed for precise police use.

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community Why I really believe the tension theory is the cause of MPB

in Research/Science 70 upvotes 4 years ago

The conversation discusses the tension theory as a cause of male pattern baldness (MPB), suggesting that scalp tension and reduced subcutaneous fat layer contribute to hair loss. Treatments mentioned include Minoxidil, finasteride, microneedling, scalp massages, and Botox.

community Do you think people of previous generations had better hair? What changed?

in Chat 2175 upvotes 5 months ago

Hair loss is less common now due to accessible treatments like finasteride, minoxidil, and hair transplants. Improved hair care, skincare, and lifestyle changes contribute to people looking younger today.

community After 11 Years On Finasteride, Unfortunately, Hair Is Starting To Thin Again. Does Hair Simply Get More Sensitive To DHT As You Age?

in Finasteride/Dutasteride 95 upvotes 1 year ago

After 11 years on Finasteride, a user's hair is thinning again, suggesting hair may become more sensitive to DHT with age. They plan to introduce Dutasteride once a week, as they cannot tolerate Minoxidil.

community 4600 - result 9 month - Dr. Carman

in Progress Pictures 256 upvotes 2 years ago

A user shared their 9-month post-hair transplant results with 4600 grafts, using only Nourkin hair vitamins, Vitamin D, and B12, and expressed satisfaction. The replies debated the necessity of medications like finasteride and minoxidil for maintaining hair health.

community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

in Research/Science 3 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

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