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GlossaryEpigenetic Changes (Epigenetic Modifications)

modifications in gene expression without altering the DNA sequence

Epigenetic changes refer to modifications in gene expression that do not involve alterations to the underlying DNA sequence. These changes can be influenced by various factors such as environment, lifestyle, and disease, and they can affect how genes are turned on or off. Common mechanisms include DNA methylation and histone modification, which can have significant impacts on biological processes and conditions, including hair growth and alopecia.

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research Molecular Characterization of HOXC8 Gene and Methylation Status Analysis of Its Exon 1 Associated with the Length of Cashmere Fiber in Liaoning Cashmere Goat

20 citations , January 2017 in “Genetica”

The methylation of the HOXC8 gene's exon 1 affects cashmere fiber length in goats.

Reshaped DNA Methylation Cooperating with Homoeolog-Divergent Expression Promotes Improved Root Traits in Synthesized Tetraploid Wheat

research Reshaped DNA Methylation Cooperating with Homoeolog-Divergent Expression Promotes Improved Root Traits in Synthesized Tetraploid Wheat

February 2024 in “New phytologist”

DNA changes in tetraploid wheat improve root growth and nitrogen use.

research Altered Methylation Pattern of the SRD5A2 Gene in the Cerebrospinal Fluid of Post-Finasteride Patients: A Pilot Study

8 citations , July 2019 in “Endocrine connections”

Finasteride affects SRD5A2 gene pattern, possibly causing lasting side effects.

research Androgen Action in the Ovary

62 citations , August 2018 in “Frontiers in Endocrinology”

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

research New Insights Into Inflammatory Memory of Epidermal Stem Cells

2 citations , May 2023 in “Frontiers in immunology”

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

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community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 1 year ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 1 year ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community So I just continue Finasteride for the rest of my life and I get to keep my hair?

in Finasteride/Dutasteride 157 upvotes 6 months ago

Finasteride can help maintain hair and slow hair loss, but its effectiveness varies by individual. Some may switch to dutasteride or add minoxidil for better results, though side effects are a concern.

community Sugar and Hair loss connections

in Research/Science 41 upvotes 10 months ago

High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

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