Epigenetic Regulations on Skin Wound Healing: Implications from Current Research

    September 2015 in “ PubMed ”
    Shoubing Zhang, Enkui Duan
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    TLDR Epigenetic changes are crucial for stem cell behavior in skin wound healing and their disruption may lead to cancer.
    The 2015 document discusses the importance of epigenetic regulation in skin wound healing, emphasizing that epigenetic changes are key in stem cell differentiation and play a significant role in adult skin stem cells during wound repair. It highlights research showing that epigenetic mechanisms, such as the downregulation of PRC2 components and upregulation of histone demethylases, are involved in skin and hair regeneration post-wounding. The paper notes that deleting H3K27 methyltransferases can slow wound closure, while certain inhibitors can enhance regeneration. It also points out the scarcity of epigenetic research in wound healing stem cells compared to homeostatic conditions, the contribution of hair follicle bulge stem cells to wound repair, and the potential balance of epigenetic modifications in regulating gene expression and cell differentiation. Furthermore, it discusses the role of myofibroblasts, angiogenesis, and the parallels between wound healing and cancer. The conclusion suggests that epigenetic regulation is crucial for stem cell behavior during wound repair and that its dysregulation could lead to carcinomas.
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