Transcriptional and Epigenetic Mechanisms Governing Epidermal Stem Cell Regulation
March 2026
in “
Frontiers in Cell and Developmental Biology
”
epidermal stem cells hair follicle stem cells transcription factors p63 YAP TCF3 SOX9 LHX2 epigenetic regulators polycomb repressive complexes histone modifiers stem cell self-renewal stem cell differentiation basal cell carcinoma psoriasis hidradenitis suppurativa epidermal regeneration single-cell technologies chromatin landscapes skin stem cells hair stem cells skin cancer skin diseases
Studysummary This review reports that transcriptional and epigenetic mechanisms in epithelial stem cells guide their fate in the epidermis and hair follicles, crucial for skin homeostasis, but disruptions can lead to disease.
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