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GlossaryEpigenetic Regulation

chemical modifications that turn genes on or off

Epigenetic Regulation refers to the process by which genes are turned on or off without changing the underlying DNA sequence. This is achieved through chemical modifications, such as DNA methylation and histone modification, which can influence gene expression and, consequently, cellular function. These changes can be influenced by environmental factors and can be heritable, playing a crucial role in development, disease, and adaptation.

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All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

research Regulation of Somatic Cell Reprogramming Through Inducible miR-302 Expression

308 citations, September 2010 in “Nucleic acids research”

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

research The Origins of Skin Diversity: Lessons From Dermal Fibroblasts

6 citations, November 2022 in “Development”

New research shows that skin diversity is influenced by different types of dermal fibroblasts and their development, especially involving the Wnt/β-catenin pathway.

research Epigenetic Control of Adult Stem Cell Function

179 citations, July 2016 in “Nature Reviews Molecular Cell Biology”

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

research Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets

39 citations, January 2016 in “PubMed”

Understanding how EDC genes are regulated can help develop better drugs for skin diseases.

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community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 151 upvotes 3 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community A warning to those using or thinking about using Dutasteride – Follow-up

in Finasteride/Dutasteride 18 upvotes 3 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 57 upvotes 1 month ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 160 upvotes 1 year ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

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