Targeting the Hippo/YAP/TAZ Signalling Pathway: Novel Opportunities for Therapeutic Interventions into Skin Cancers

    August 2022 in “ Experimental dermatology ”
    Alexander Howard, Jodie Bojko, Benjamin P. Flynn … Gernot Walko
    Studysummary This review discusses the role of YAP/TAZ proteins in skin cancer physiology and tumorigenesis, and the potential of targeting these proteins in skin cancer treatments, but presents no new experimental findings.
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    Research cited in this study 9

    1. Targeting the Hippo/YAP/TAZ Signalling Pathway: Novel Opportunities for Therapeutic Interventions into Skin Cancers Experimental dermatology · 2022
    2. Stem Cell Dynamics, Migration, and Plasticity During Wound Healing Nature Cell Biology · 2018
    3. YAP And TAZ Are Essential For Basal And Squamous Cell Carcinoma Initiation EMBO Reports · 2018
    4. Skin Cell Heterogeneity in Development, Wound Healing, and Cancer Trends in cell biology · 2018
    5. Homeostasis, Regeneration, And Tumor Formation In The Mammalian Epidermis The International Journal of Developmental Biology · 2018
    6. Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis Development · 2016
    7. Basal Cell Carcinoma: Molecular Biology and Potential New Therapies Journal of Clinical Investigation · 2012
    8. Basal Cell Carcinomas in Mice Arise from Hair Follicle Stem Cells and Multiple Epithelial Progenitor Populations Journal of Clinical Investigation · 2011
    9. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011