Single Cell Analysis of Transcriptome and Open Chromatin Reveals the Dynamics of Hair Follicle Stem Cell Aging

    July 2023 in “ Frontiers in Aging ”
    Chi Zhang, Dongmei Wang, Robin D. Dowell, Rui Yi
    TLDR Hair follicle stem cells change states with age, affecting hair growth and aging.
    This study used single-cell RNA sequencing (scRNAseq) and single-cell ATAC sequencing (scATACseq) to analyze the aging process of hair follicle stem cells (HF-SCs) in mice from P28 to 24 months. The researchers found that aging HF-SCs exhibit reduced open chromatin regions, indicating compromised differentiation potential, and increased regions associated with prolonged quiescence. They also identified a unique migratory niche (migNiche) population and observed that niche cells accumulate gene expressions associated with cellular stress as they age. The study highlights the importance of the microenvironment in HF-SC aging and suggests potential targets for future research into hair follicle aging and therapeutic interventions.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 1000+ results

      community TDM-105795 phase 2 results are in!

      in Research/Science  28 upvotes 10 months ago
      TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Hair follicle cloning is already possible

      in Chat  38 upvotes 2 months ago
      Hair follicle cloning is claimed to be possible but not widely available due to potential safety issues, such as cancer risks. Current treatments like finasteride and dutasteride are not effective for everyone, and there is frustration over limited access to these medications.

      community Do hair follicles dies or are dormant ?

      in Finasteride/Dutasteride  92 upvotes 3 weeks ago
      Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

    Similar Research

    5 / 1000+ results