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Glossarytranscriptome

complete set of RNA molecules expressed in a cell

The transcriptome is the complete set of RNA molecules, including messenger RNA (mRNA), produced in a cell or a population of cells. It reflects the genes that are actively being expressed at any given time, providing insights into cellular function and regulation. For professionals, analyzing the transcriptome can reveal how cells respond to various conditions and can be crucial for understanding diseases like alopecia at a molecular level.

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research Transcriptome Sequencing Reveals Differences Between Primary and Secondary Hair Follicle-Derived Dermal Papilla Cells of the Cashmere Goat

81 citations , September 2013 in “PLoS ONE”

Primary and secondary hair follicle cells in Cashmere goats have different gene expressions affecting hair growth and size.

research Transcriptome Reveals Long Non-Coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin

37 citations , May 2018 in “Frontiers in physiology”

Certain RNA molecules are important for the development of wool follicles in sheep.

Differential Gene Expression Analysis Between Anagen and Telogen of Capra Hircus Skin Based on the De Novo Assembled Transcriptome Sequence

research Differential Gene Expression Analysis Between Anagen and Telogen of Capra Hircus Skin Based on the De Novo Assembled Transcriptome Sequence

31 citations , March 2013 in “Gene”

Signaling pathways are crucial for hair growth in goats.

research Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis

21 citations , January 2018 in “Journal of Investigative Dermatology”

Rats can't grow new hair follicles after skin wounds, unlike mice, due to differences in gene expression and response to WNT signaling.

research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

13 citations , September 2022 in “Biomolecules”

The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.

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community Journey against alopecia - Finasteride 3 month

in Progress Pictures 17 upvotes 4 years ago

A 26-year-old man from France started experiencing hair loss in September 2020 and began using finasteride in June 2021, reporting some improvement after three months without side effects. He plans to continue finasteride for a year before considering additional treatments like minoxidil or dermarolling.

community Results of Procyanidin B2 in clinical studies

in Treatment 11 upvotes 5 years ago

Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 59 upvotes 3 weeks ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 441 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.