Cultivation of Hair Matrix Cells from Cashmere Goat Skins and Exemplified Applications

August 2020 in “ Animals ”

Sen Ma, Lamei Wang, Bo Zong, Ying Wang, Xiaolong Wang, Yinghua Shi, Yuxin Yang

hair matrix cells HMCs cashmere goat skins RPMI 1640 MEM media calcium all-trans retinoic acid ATRA dermal papilla cells DPCs gene expression morphology hair growth mechanisms hair loss treatments

TLDR Researchers found a way to grow cashmere goat hair cells in a lab and discovered that certain conditions improve these cells' growth and characteristics.

Researchers successfully isolated and cultivated hair matrix cells (HMCs) from cashmere goat skins, optimizing culture conditions with RPMI 1640 and MEM media for effective proliferation. Higher calcium levels and all-trans retinoic acid (ATRA) significantly promoted HMC growth and differentiation. The study highlighted distinct differences between HMCs and dermal papilla cells (DPCs) in gene expression and morphology. These findings provided a valuable model for exploring hair growth mechanisms and developing treatments for hair loss, as well as improving cashmere fiber quality.

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research Thymosin β4 Identified by Transcriptomic Analysis from Hair Follicle Anagen to Telogen Promotes Proliferation of Secondary Hair Follicle Dermal Papilla Cells in Albas Cashmere Goat

3 citations , March 2020 in “International Journal of Molecular Sciences”

Thymosin β4 helps increase hair growth in Cashmere goats.

research Synchronous Profiling and Analysis of mRNAs and ncRNAs in the Dermal Papilla Cells from Cashmere Goats

17 citations , June 2019 in “BMC genomics”

Non-coding RNAs help control hair growth in cashmere goats.

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

research The Intragenic mRNA-microRNA Regulatory Network During Telogen-Anagen Hair Follicle Transition in the Cashmere Goat

13 citations , September 2018 in “Scientific Reports”

The research found that a complex gene network, controlled by microRNAs, is important for hair growth in cashmere goats.

research Whole-Genome Bisulfite Sequencing of Goat Skins Identifies Signatures Associated with Hair Cycling

28 citations , August 2018 in “BMC genomics”

DNA methylation changes are linked to hair growth cycles in goats.

research Effects of All-Trans Retinoic Acid on Goat Dermal Papilla Cells Cultured In Vitro

4 citations , July 2018 in “Electronic Journal of Biotechnology”

All-trans retinoic acid at high doses harms goat hair growth cells and could be bad for hair growth.

research Activation of Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth

26 citations , July 2016 in “PLOS ONE”

Activating β-catenin in certain skin cells speeds up hair growth in mice.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

91 citations , February 2009 in “Journal of biological chemistry/The Journal of biological chemistry”

DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.

research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

48 citations , July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Retinoic acid production and signaling in hair follicles are regulated by location and timing, affecting hair growth and cycling.

research Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

65 citations , September 2006 in “Journal of biological chemistry/The Journal of biological chemistry”

The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.

research The Hair Cycle

375 citations , February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations , September 2005 in “PLoS biology”

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations , June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.