Cultivation of Hair Matrix Cells from Cashmere Goat Skins and Exemplified Applications

August 2020 in “ Animals ”

Sen Ma, Lamei Wang, Bo Zong, Ying Wang, Xiaolong Wang, Yinghua Shi, Yuxin Yang

hair matrix cells HMCs cashmere goat skins RPMI 1640 MEM media calcium all-trans retinoic acid ATRA dermal papilla cells DPCs gene expression morphology hair growth mechanisms hair loss treatments

TLDR Researchers found a way to grow cashmere goat hair cells in a lab and discovered that certain conditions improve these cells' growth and characteristics.

Researchers successfully isolated and cultivated hair matrix cells (HMCs) from cashmere goat skins, optimizing culture conditions with RPMI 1640 and MEM media for effective proliferation. Higher calcium levels and all-trans retinoic acid (ATRA) significantly promoted HMC growth and differentiation. The study highlighted distinct differences between HMCs and dermal papilla cells (DPCs) in gene expression and morphology. These findings provided a valuable model for exploring hair growth mechanisms and developing treatments for hair loss, as well as improving cashmere fiber quality.

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Research cited in this study

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Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

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