The Transient Role of Calcium and Vitamin D During the Developmental Hair Follicle Cycle

    March 2016 in “ Journal of Investigative Dermatology ”
    Leila J. Mady, Dare V. Ajibade, Connie Hsaio, Arnaud Teichert, Chak Fong, Yongmei Wang, Sylvia Christakos, Daniel D. Bikle
    TLDR Vitamin D and calcium are essential for normal hair growth.
    The study investigated the role of 1,25-dihydroxyvitamin D3 and calcium in hair follicle cycling using calbindin-D9k knockout (KO) mice. Pups from KO mothers on a vitamin D-deficient, low-calcium diet developed transient alopecia starting at 13 days, with complete hair loss by 20-23 days and spontaneous recovery by 28 days. Histological analysis revealed dystrophic hair follicles, increased apoptosis, and hyperplastic epidermis. The alopecia was mitigated when mothers were fed a high-vitamin D/high-calcium diet. The findings suggested that maternal vitamin D and calcium levels were crucial for normal hair follicle development in calbindin-D9k KO pups.
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