Effects of All-Trans Retinoic Acid on Goat Dermal Papilla Cells Cultured In Vitro

    May 2018 in “ Electronic Journal of Biotechnology ”
    Sen Ma, Guangxian Zhou, Yulin Chen
    Image of study
    TLDR All-trans retinoic acid at high doses harms goat hair growth cells and could be bad for hair growth.
    The study from 2018 examined the impact of all-trans retinoic acid (ATRA) on goat dermal papilla cells (DPCs) in vitro, revealing that high doses of ATRA significantly reduced cell viability, proliferation, and induced apoptosis and cell cycle arrest in these cells. ATRA treatment also downregulated the expression of fibroblast growth factor 7 (Fgf7), a crucial stimulator of hair growth, and increased the expression of the retinoic acid receptor Rarß. These findings suggest that ATRA negatively affects hair growth by impairing the function of DPCs and altering the expression of genes involved in hair biology. The study indicates that excess ATRA could be detrimental to hair growth, and further research is needed to understand its effects on other hair follicle cells. The research was funded by the National Natural Science Foundation of China and the China Agriculture Research System.
    Discuss this study in the Community →

    Research cited in this study

    16 / 16 results

    Related Community Posts Join

    6 / 1000+ results

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  738 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 2 weeks ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community Dutasteride for trans men? (Topical vs oral?)

      in Transgender 4 months ago
      The conversation discusses using dutasteride, both topical and oral, for hair loss in trans men, considering potential side effects like depression and libido issues. The user is exploring options including topical solutions with minoxidil, retinoic acid, and hydrocortisone, and plans to start microneedling.

      community Haircafe - TOPICAL minoxidil is an anti aging drug

      in Minoxidil  244 upvotes 2 months ago
      Topical minoxidil may cause skin aging effects like wrinkles and dark circles, possibly due to its alcohol content, while oral finasteride is reported to make users look younger. Switching to oral minoxidil or using moisturizers might help reduce these skin issues.

    Related Research

    7 / 7 results