HX109 Herbal Extract Promotes Hair Growth by Regulating Cell Cycle in Hair Follicle Dermal Papilla Cells
March 2023
in “
Asian Journal of Beauty and Cosmetology
”
HX109 Taraxacum officinale Cuscuta australis Nelumbo nucifera hair follicle dermal papilla cells HFDPC cell proliferation apoptosis cyclin B1 bax/bcl-2 ratio S-G2/M phase transition C57BL/6J mice oral administration hair growth products dandelion dodder lotus hair follicle cells cell growth cell death cell cycle mice hair growth
TLDR HX109 herbal extract helps hair grow by boosting cell growth and reducing cell death.
The study found that the herbal extract HX109, composed of Taraxacum officinale, Cuscuta australis, and Nelumbo nucifera, promotes hair growth by enhancing cell proliferation and reducing apoptosis in hair follicle dermal papilla cells (HFDPC) and C57BL/6J mice. HX109 increased cyclin B1 expression and decreased the bax/bcl-2 ratio, facilitating the S-G2/M phase transition in HFDPCs. Oral administration of HX109 at 300 mg/kg significantly promoted hair growth in mice. The results suggest HX109 as a potential ingredient for hair growth products without the hormonal side effects associated with finasteride.
