HX109 Herbal Extract Promotes Hair Growth by Regulating Cell Cycle in Hair Follicle Dermal Papilla Cells

March 2023 in “ Asian Journal of Beauty and Cosmetology ”

Se‐Young Choi, Joo Seok Song, Su‐Hyun Han, Jung‐Kyu Lee, Wonwoo Lee

Studysummary This study found that the herbal extract HX109 promoted hair growth in mice by increasing cell viability and enhancing hair regrowth, with the effects increasing as doses rose.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study found that the herbal extract HX109, composed of Taraxacum officinale, Cuscuta australis, and Nelumbo nucifera, promotes hair growth by enhancing cell proliferation and reducing apoptosis in hair follicle dermal papilla cells (HFDPC) and C57BL/6J mice. HX109 increased cyclin B1 expression and decreased the bax/bcl-2 ratio, facilitating the S-G2/M phase transition in HFDPCs. Oral administration of HX109 at 300 mg/kg significantly promoted hair growth in mice. The results suggest HX109 as a potential ingredient for hair growth products without the hormonal side effects associated with finasteride.

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