A Pilot Clinical Study of Hair Grafting in Chronic Leg Ulcers

October 2012 in “ Wound Repair and Regeneration ”

Francisco Jiménez, C Garde, Enrique Poblet, Begoña Jimeno, Jesús Ortiz, María Luisa Martínez, Araika Gutiérrez‐Rivera, Virginia Pérez‐López, Usue Etxaniz, Corina Naveda, José L. Higuera, Nerea Egüés, Eduardo Escario, Ander Izeta

autologous scalp follicular grafts hair follicle grafting epithelialization neovascularization dermal reorganization

TLDR Hair follicle grafting can help heal chronic leg ulcers.

This pilot clinical study investigated the feasibility and healing potential of autologous scalp follicular grafts in treating chronic leg ulcers. The study included 10 patients with ulcers averaging 36.8 cm² in size and lasting 10.5 years. Each ulcer had a 2×2 cm "experimental" square that received 20 hair grafts and a control square that did not. After 18 weeks, the experimental squares showed a 27.1% reduction in ulcer area compared to a 6.5% reduction in the control squares, with significant improvements in epithelialization, neovascularization, and dermal reorganization. The study concluded that hair follicle grafting is a safe and promising outpatient treatment for nonhealing chronic leg ulcers.

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