The Roles of Activins in Repair Processes of the Skin and the Brain

    Barbara Munz, Yvonne P. Tretter, Moritz Hertel, Felix Engelhardt, Christian Alzheimer, Sabine Werner
    TLDR Activin A helps heal skin wounds and protects the brain after injury.
    The study demonstrated that activin A played a significant role in skin and brain repair processes. Transgenic mice overexpressing activin A showed enhanced wound healing, characterized by increased granulation tissue and re-epithelialization. These mice were smaller with thicker skin due to connective tissue replacement. In brain injury models, activin A expression was rapidly upregulated, and exogenous application of recombinant activin A rescued neurons from acute cell death. The findings suggested that activin A could be a target for developing new treatments for stroke and brain trauma.
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