Activin B Promotes BMSC-Mediated Cutaneous Wound Healing by Regulating Cell Migration via the JNK-ERK Signaling Pathway
September 2014
in “
Cell Transplantation
”
TLDR Activin B improves wound healing and hair growth by helping stem cells move using certain cell signals.
The study from 9 years ago demonstrated that Activin B significantly enhances cutaneous wound healing and hair follicle regeneration when used in conjunction with bone marrow-derived mesenchymal stem cells (BMSCs) in a rat model. The combination treatment outperformed the control groups treated with PBS, Activin B, or BMSCs alone. In vitro, Activin B was shown to induce actin stress fiber formation and promote BMSC migration, effects that were mediated through the JNK and ERK signaling pathways, but not the p38 pathway. The study, which involved 24 rats and in vitro BMSC experiments, concluded that Activin B could be a promising agent for improving BMSC-mediated wound healing by regulating cell migration through specific signaling pathways.