TLDR Activin B improves wound healing and hair growth by helping stem cells move using certain cell signals.
The study from 9 years ago demonstrated that Activin B significantly enhances cutaneous wound healing and hair follicle regeneration when used in conjunction with bone marrow-derived mesenchymal stem cells (BMSCs) in a rat model. The combination treatment outperformed the control groups treated with PBS, Activin B, or BMSCs alone. In vitro, Activin B was shown to induce actin stress fiber formation and promote BMSC migration, effects that were mediated through the JNK and ERK signaling pathways, but not the p38 pathway. The study, which involved 24 rats and in vitro BMSC experiments, concluded that Activin B could be a promising agent for improving BMSC-mediated wound healing by regulating cell migration through specific signaling pathways.
5 citations,
January 2013 in “Cells Tissues Organs” Activin B helps start and grow hair follicles in mice.
38 citations,
September 2011 in “PLOS ONE” Activin B helps heal skin wounds and grow hair by activating a specific cell signaling pathway.
81 citations,
September 2005 in “The American journal of pathology” Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.
163 citations,
October 2001 in “EMBO journal” Overexpressing follistatin in mice delays wound healing and reduces scar size.
18 citations,
December 2018 in “Expert Opinion on Biological Therapy” Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.
4 citations,
January 2017 in “PubMed” Epidermal growth factor helps stem cells heal wounds and regenerate hair follicles faster.
April 2024 in “Military Medical Research/Military medical research” Cellular and immunotherapies show promise for healing chronic wounds but need more research.
TLR3 signaling enhances the immunosuppressive properties of human periodontal ligament stem cells.
36 citations,
September 2009 in “Journal of Cellular and Molecular Medicine” New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
