TLDR Epidermal growth factor helps stem cells heal wounds and regenerate hair follicles faster.
In a study conducted in 2017, researchers found that epidermal growth factor (EGF) significantly enhanced the wound healing and hair follicle regeneration capabilities of mesenchymal stem cells (MSCs). The study involved both in vivo and in vitro experiments, including the transplantation of excisional wounds in rats with different collagen-chitosan scaffolds. The results showed that wounds were significantly smaller and hair grew faster in the group treated with both MSCs and EGF. Histological analysis revealed more hair follicles, sebaceous glands, and newly formed blood vessels in this group compared to the group treated with MSCs alone. The study concluded that EGF can promote MSC-mediated wound healing and hair follicle regeneration, suggesting that the combined administration of MSCs and EGF could be a promising therapeutic strategy for wound management and hair follicle regeneration.
44 citations,
July 2016 in “Stem Cells Translational Medicine” Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.
256 citations,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Growing human skin cells in a 3D environment can stimulate new hair growth.
45 citations,
April 2013 in “Cell Transplantation” Activin B improves wound healing and hair growth by helping stem cells move using certain cell signals.
36 citations,
April 2013 in “Cell and Tissue Research” Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.
66 citations,
May 2012 in “Scientific Reports” Scientists successfully created and transplanted bioengineered hair follicles that function like natural ones, suggesting a new treatment for hair loss.
499 citations,
September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
15 citations,
February 2011 in “Journal of Tissue Engineering and Regenerative Medicine” The best method for transplanting skin cells to regenerate hair follicles is the Hemi-vascularized sandwich method, as it produces more mature follicles and promotes hair growth.
89 citations,
October 2003 in “Biology of the Cell” Galectin-1 helps in RNA processing in cell nuclei.
Dermal stem cells help regenerate hair follicles and heal skin wounds.
359 citations,
January 2015 in “Cold Spring Harbor Perspectives in Medicine” Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
156 citations,
October 2012 in “Seminars in Cell & Developmental Biology” Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.
23 citations,
June 2012 in “PLOS ONE” KLF4 is important for maintaining skin stem cells and helps heal wounds.
