Neurobiology, Stem Cell Biology, and Immunology: An Emerging Triad for Understanding Tissue Homeostasis and Repair
October 2022
in “
Annual review of cell and developmental biology
”
peripheral nervous system PNS skin hematopoietic system sensory neurons sympathetic nervous system parasympathetic nervous system stem cell behaviors immune responses sympathetic nerve endings hair follicle stem cells HFSCs homeostasis hair growth stress hair graying melanocyte stem cells MeSCs overactivation wound repair hematopoietic stem cells HSCs pathogens therapeutic interventions
TLDR The nervous system helps control stem cell behavior and immune responses, affecting tissue repair and maintenance.
The document discusses the role of the peripheral nervous system (PNS) in tissue homeostasis and repair, particularly in the skin and hematopoietic system. It highlights the involvement of sensory neurons, sympathetic nervous system, and parasympathetic nervous system in modulating stem cell behaviors and immune responses. The document specifically discusses the interaction between sympathetic nerve endings and hair follicle stem cells (HFSCs) in maintaining homeostasis and growth. It also explains how stress can cause hair graying by depleting melanocyte stem cells (MeSCs) through overactivation of the sympathetic nervous system. The document further explores the role of sensory nerves in wound repair, cancer development, and the regulation of hematopoietic stem cells (HSCs). It also discusses how sensory nerves can sense pathogens and modulate immune responses. The findings suggest new opportunities for therapeutic interventions.
