The Cellular Basis of Mechanosensory Merkel-Cell Innervation During Development

    February 2019 in “ eLife ”
    Blair A. Jenkins, Natalia M. Fontecilla, Ping Lu … Ellen A Lumpkin
    Studysummary This study identified key cells and pathways needed for the development of touch receptor patterns in mouse skin, notably that certain keratinocytes are crucial for innervation patterns, while Merkel cells and BMP signaling have distinct roles.
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    Research cited in this study 9

    1. The Structure and Organization of Lanceolate Mechanosensory Complexes at Mouse Hair Follicles eLife · 2014
    2. Early Inductive Events in Ectodermal Appendage Morphogenesis Seminars in cell & developmental biology · 2014
    3. The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons Cell · 2011
    4. Exploiting the Keratin 17 Gene Promoter to Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005
    5. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    6. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004
    7. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    8. Dynamics of Merkel Cell Patterns in Developing Hair Follicles in the Dorsal Skin of Mice, Demonstrated by a Monoclonal Antibody to Mouse Keratin 8 Cells Tissues Organs · 1995
    9. Receptor Types in Cat Hairy Skin Supplied by Myelinated Fibers Journal of neurophysiology · 1968

    Related research 2

    1. In Vitro Co-Culture Models of Merkel Cell-Neurite Complex in Touch Domes Journal of Investigative Dermatology · 2021
    2. The Cellular Basis of Mechanosensory Merkel-Cell Innervation During Development eLife · 2019