In Vitro Co-Culture Models of Merkel Cell-Neurite Complex in Touch Domes

October 2021 in “ Journal of Investigative Dermatology ”

Yoko Toba-Ichihashi, T. Yoshino, Takamoto Suzuki, Tetsuhito Sakurai, Yasushi Suga, Mitsutoshi Tominaga, Kenji Takamori

Merkel cell-neurite complex hair growth mechanical stimulation Merkel cell carcinoma MCC14/2 dorsal root ganglion neurons DRG neurons c-Fos Draxin PI3K/AKT axon investigation system AXIS synaptophysin Merkel cell DRG PI3K AKT

Studysummary In this research, investigators used in vitro models to study the Merkel cell-neurite complex and reported that mechanical stimulation, similar to gentle touch, can induce molecular changes that are potentially relevant to hair growth, thus contributing to the understanding of its underlying mechanisms.

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