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GlossaryMerkel cells

specialized skin cells that detect touch and pressure

Merkel cells are specialized skin cells located in the epidermis, particularly in areas with high tactile sensitivity like fingertips. They function as mechanoreceptors, meaning they help detect touch and pressure, and are connected to nerve endings to transmit sensory information to the brain.

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ELife Assessment: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

research ELife Assessment: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

February 2024

Meis2 is essential for touch sensation and proper nerve connection to touch receptors in certain skin areas of mice.

research In Vitro Co-Culture Models of Merkel Cell-Neurite Complex in Touch Domes

October 2021 in “Journal of Investigative Dermatology”

The study concluded that the developed models are effective for studying hair growth mechanisms and testing new treatments.

research Partial Interchangeability of Fz3 and Fz6 in Tissue Polarity Signaling for Epithelial Orientation and Axon Growth and Guidance

28 citations, October 2014 in “Development”

Fz3 and Fz6 can partially replace each other in tissue polarity and axon guidance.

research SOX2 in the Skin: Roles in Biology and Pathology

1 citations, September 2015 in “Elsevier eBooks”

SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.

research Merkel Cell Carcinoma with Fungal Infection: A Case Report

April 2019 in “Journal of Investigative Dermatology”

Surgery and antifungal medication are effective for treating Merkel cell carcinoma with fungal infection.

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