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research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones

197 citations, January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

research Expression of Hypothalamic-Pituitary-Thyroid Axis Related Genes in Human Skin

155 citations, December 2002 in “Journal of Investigative Dermatology”

Thyroid-related genes are active in skin cells and may affect autoimmune conditions.

research Maternal Influence on Child HPA Axis: A Prospective Study of Cortisol Levels in Hair

122 citations, October 2013 in “PEDIATRICS”

Maternal stress during pregnancy affects a child's stress levels.

research Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male

70 citations, March 2016 in “Urologic Clinics of North America”

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

research Physical Properties of Human Hair: Evaluation of Bending Stress by Measuring the Major and Minor Axis of Human Hair

10 citations, January 2002 in “Nihon Keshouhin Gijutsushakaishi/Journal of S C C./Nihon Keshouhin Gijutsushakai kaishi”

The cuticle significantly contributes to hair stiffness, making up about 60% of the total bending stress.

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community Is hydrocortisone that bad for your scalp?

in Minoxidil 1 upvotes 2 months ago

Hydrocortisone is not recommended for long-term use on the scalp due to potential side effects like thinning and steroid-related issues. Alternatives like foam minoxidil or oral minoxidil are suggested, though foam may be less effective.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 6 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Anyone used CB-03-01 (clascoterone), is it worth it, too risky??

in Research/Science 2 upvotes 6 months ago

The user experienced side effects from low-dose topical finasteride and is considering using clascoterone (CB-03-01) despite concerns about its risks and cost. They seek advice on its effectiveness and potential side effects compared to other treatments like alfatradiol and fluridil.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 47 upvotes 7 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 1 year ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

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