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research Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol

489 citations , June 2005 in “The FASEB Journal”

This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.

research Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones

197 citations , January 2019 in “Neuropsychopharmacology”

This review discusses sex differences in the neuroendocrine response to stress, focusing primarily on rodent studies, and highlights open questions about the roles of gonadal hormones and sex chromosomes.

research Expression of Hypothalamic–Pituitary–Thyroid Axis RelatedGenes in the Human Skin

155 citations , December 2002 in “Journal of Investigative Dermatology”

This study found that thyroid-stimulating hormone receptors are functionally expressed in various skin cells, implying potential physiological and pathological roles in skin, especially in conditions like autoimmune diseases.

research Maternal Influence on Child HPA Axis: A Prospective Study of Cortisol Levels in Hair

122 citations , October 2013 in “PEDIATRICS”

This study observed that cortisol concentrations in hair, indicating prolonged stress, are correlated between mothers and young children, suggesting potential heritable traits or maternal influence.

research Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles

95 citations , August 2013 in “Journal of Investigative Dermatology”

HPT axis hormones boost mitochondrial function and growth in hair follicles, potentially aiding hair health.

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Clinics

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Hair Loss Treatments
Axis Stem Cell InstituteKirkland, WA · US

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community CB-03-01 / Breezula Personal Results

17 upvotes 7 months ago

The user shared their experience with CB-03-01 (Breezula/Clascoterone) for hair loss, noting reduced shedding and improved hair appearance but experiencing significant sleep disturbances and low energy due to HPA axis suppression. They decided to stop using it due to these side effects and are waiting for GT20029 as an alternative.

community EMA is re-examining Winlevi (clascoterone at lower concentration)

8 upvotes 1 year ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community There’s actually a quite good chance that next year, we might see a new treatment get FDA approval for the first time in nearly three decades.

78 upvotes 1 year ago

Breezula, a potential new hair loss treatment, may receive FDA approval soon, but it is expected to be a weaker alternative to finasteride and minoxidil. Concerns include its twice-daily application and possible side effects like HPA axis suppression.

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