Inhibitory Effect of Tianeptine on Catagen Induction in Alopecia Areata-Like Lesions Induced by Ultrasonic Wave Stress in Mice

In 2013, a study on mice demonstrated that tianeptine, an antidepressant, could potentially prevent stress-induced hair loss. Mice subjected to ultrasonic wave stress to induce alopecia areata-like lesions showed improved hair regrowth, thicker hair shafts, and increased anagen hair follicles when treated with tianeptine before and after the stress. The treatment also led to decreased mast cell degranulation, reduced apoptosis in hair follicles, and increased collagen and elastic fiber synthesis, along with recovery of vitamin D receptor expression. However, there was no change in neuropeptides substance P and calcitonin gene-related peptide levels. These findings suggest tianeptine might suppress catagen induction in a stress-induced alopecia areata mouse model, but further research is required to explore its effects on humans.