TLDR Combining epinephrine with a steroid may help regrow hair in severe alopecia areata cases.
This study explores a novel treatment for alopecia areata (AA) by combining intralesional triamcinolone acetonide (ILTA) with epinephrine and lidocaine, instead of the traditional normal saline. The authors report two severe AA cases that showed seemingly permanent hair regrowth with this new regimen. They hypothesize that the local vasoconstriction caused by epinephrine enhances the effectiveness of ILTA and that epinephrine may also have an independent role in promoting hair regrowth.
148 citations,
March 2022 in “The New England Journal of Medicine” Baricitinib was effective in treating alopecia areata in two major trials.
41 citations,
September 2018 in “Australasian journal of dermatology” No systemic treatment for alopecia areata has strong evidence of effectiveness.
Combining epinephrine with a steroid may help regrow hair in severe alopecia areata cases.
1 citations,
October 2020 in “Journal of Cosmetic Dermatology” Using minoxidil and tofacitinib together can effectively treat severe hair loss.
June 2020 in “Journal of skin and stem cell” The patient's hair loss from alopecia totalis returned despite initial successful treatment.
March 2020 in “QJM: An International Journal of Medicine” Standard intralesional corticosteroids are the best treatment for patchy alopecia areata.
3 citations,
July 2017 in “International journal of medicine” Intralesional triamcinolone acetonide effectively treats alopecia areata, as shown by significant improvements in hair regrowth and dermoscopic indicators.
54 citations,
March 1987 in “Journal of The American Academy of Dermatology” 3% topical minoxidil effectively treats extensive alopecia areata with few side effects.
