Hair growth-modulation by adrenergic drugs

    August 1999 in “ Experimental Dermatology
    Eva M.J. Peters, Marcus Maurer, Vladimir A. Botchkarev, D. S. Gordon, Ralf Paus
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    TLDR Certain drugs can cause early hair growth in mice by affecting the nerves.
    In the 1999 study, researchers found that adrenergic drugs, specifically guanethidine and 6-hydroxydopamine (6-OHDA), induced premature hair growth in C57BL/6 mice. Over 80% of guanethidine-treated mice and about 65% of 6-OHDA-treated mice exhibited premature skin darkening and hair growth by day 20 post-treatment, while less than one-third of control animals showed these changes. Histological analysis confirmed mature anagen VI hair follicles in treated areas. The study did not observe similar effects with the B2-adrenoreceptor agonist isoproterenol. These results suggest that sympathetic nerves significantly influence hair growth and that manipulating these nerves could be a potential therapeutic approach for hair growth disorders.
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