Mediator1: An Important Intermediary of Vitamin D Receptor-Regulated Epidermal Function and Hair Follicle Biology

    March 2012 in “ Journal of Investigative Dermatology ”
    Wendy B. Bollag, Wendy B. Bollag
    Studysummary In their mouse study, Oda et al. found that removing the MED1 gene in the skin led to hair loss and changes in epidermal cell differentiation, indicating MED1's significant role in these processes.
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    Research cited in this study 11

    1. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    2. Does D Matter? The Role of Vitamin D in Hair Disorders and Hair Follicle Cycling Dermatology Online Journal · 2010
    3. Vitamin D and the Skin Journal of bone and mineral metabolism · 2010
    4. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    5. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    6. Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology · 2005
    7. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004
    8. 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    9. Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    10. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001
    11. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice Endocrinology · 1998