Apoptosis and Cutaneous Biology
June 1997
in “
Journal of The American Academy of Dermatology
”
apoptosis keratinocytes melanocytes p53 UV radiation sunburn cells hair follicle cycling scarring alopecia alopecia areata telogen effluvium androgenetic alopecia irradiation cytotoxic drugs programmed cell death skin cells skin pigment cells tumor suppressor protein ultraviolet radiation sunburned cells hair growth cycle scarring hair loss patchy hair loss shedding hair loss male pattern baldness radiation therapy chemotherapy drugs
TLDR Apoptosis is crucial for healthy skin and treating skin diseases.
The document from June 1997 reviews the role of apoptosis in skin biology, highlighting its importance in maintaining tissue homeostasis and its implications for various skin diseases and conditions. Apoptosis, a programmed cell death process, is characterized by specific morphological changes and is distinct from oncosis, a pathological cell death. The review discusses the molecular mechanisms of apoptosis, the role of key proteins, and the significance of apoptosis in preventing viral spread and unregulated cell growth, such as cancer. It also explores the role of apoptosis in keratinocytes and melanocytes, the importance of p53 in the skin's response to UV radiation, and the protective nature of sunburn cells. Furthermore, the document examines apoptosis in the context of hair follicle cycling, scarring alopecia, alopecia areata, telogen effluvium, androgenetic alopecia, and the effects of treatments like irradiation or cytotoxic drugs. It concludes with the potential therapeutic applications of apoptosis in treating skin diseases and the necessity of understanding this process for developing new treatments for human diseases.
