Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing
March 2022
in “
Frontiers in Bioengineering and Biotechnology
”
bioengineered scaffolds cutaneous wound healing pro-regenerative scaffolds regenerative immune responses natural biomaterials quaternized chitosan hydrogels synthetic materials hybrid materials immunomodulatory biomaterials bioactive molecules stem cells macrophage polarization growth factors chitosan hydrogels
TLDR Bioengineered scaffolds help heal skin wounds, but perfect treatments are still needed.
The document reviewed advancements in bioengineered scaffolds for cutaneous wound healing, emphasizing the development of pro-regenerative scaffolds that activate regenerative immune responses and promote full skin regeneration. It highlighted the use of natural, synthetic, and hybrid materials, with natural biomaterials like quaternized chitosan hydrogels showing promise due to antibacterial properties, while synthetic materials offered tunable properties but often caused inflammation. Hybrid materials combined the strengths of both to improve wound healing applications. The review also discussed the role of immunomodulatory biomaterials, bioactive molecules, and stem cells, noting the importance of macrophage polarization and growth factors in enhancing healing. Despite progress, challenges remained in achieving perfect skin regeneration and translating these technologies into clinical applications, with a need for more effective and cost-efficient solutions.
