Microskin-Inspired Injectable MSC-Laden Hydrogels for Scarless Wound Healing with Hair Follicles

    April 2020 in “ Advanced Healthcare Materials ”
    Xin Zheng, Zhaozhao Ding, Weinan Cheng, Qiang Lü, Xiangdong Kong, Xiaozhong Zhou, Guozhong Lu, David L. Kaplan
    TLDR MSC-laden hydrogels enable scarless wound healing with hair growth.
    The study developed mesenchymal stem cell (MSC)-laden hydrogels for scarless wound healing with hair follicles, using microgels composed of aligned silk nanofibers to load MSCs. These hydrogels protected and stabilized MSCs in wounds, promoting angiogenesis and macrophage phenotype switching, which facilitated functional recovery. Compared to MSC-free hydrogels, the MSC-laden hydrogels resulted in faster healing and scarless tissue formation with hair follicles. The system's tunability was demonstrated by adjusting the ratio of silk nanofibers and MSCs, marking the first report of scarless skin regeneration with hair follicles using silk materials. The findings suggested potential for future in vivo studies to enhance clinical skin regeneration without scarring.
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