Macrophage Related Chronic Inflammation in Non-Healing Wounds

    June 2021 in “ Frontiers in Immunology ”
    Meirong Li, Qian Hou, Lingzhi Zhong, Yali Zhao, Xiaobing Fu
    TLDR Macrophage issues cause chronic wound inflammation, but therapies can help.
    The document reviewed the role of macrophages in chronic wound healing, focusing on their critical function in transitioning through different phenotypes, particularly from pro-inflammatory M1 to anti-inflammatory M2. It highlighted that dysfunction in these transitions, often due to conditions like aging, obesity, and diabetes, leads to stalled healing processes. The review discussed macrophage heterogeneity and their potential as therapeutic targets, suggesting that manipulating macrophage subpopulations could enhance wound repair. Various therapeutic strategies were explored, including systemic and local treatments, to restore macrophage function and promote healing. The document emphasized the potential of multi-target treatments and the need for further research to fully understand macrophage plasticity and improve therapeutic strategies for chronic wounds. Additionally, it noted the involvement of macrophages in hair follicle regeneration, indicating their broader regenerative potential.
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