Sustained Release of Inhibitor from Bionic Scaffolds for Wound Healing and Functional Regeneration

In 2020, researchers developed a bionic composite scaffold (CSNF-SB) that incorporated a GSK-3 inhibitor, SB216763, into silk fibroin nanofibers mixed with chitosan to promote wound healing and skin regeneration, including hair follicle neogenesis. The scaffolds enabled sustained release of the drug for over 21 days, enhancing cell adhesion, proliferation, and ß-catenin expression in vitro. In vivo studies using 15 male C57BL/c mice showed that the drug-loaded scaffolds resulted in faster and more effective wound healing compared to drug-free controls. The study concluded that these scaffolds offer a promising approach for functional skin recovery, with the potential to improve tissue regeneration applications.