Sustained Release of Inhibitor from Bionic Scaffolds for Wound Healing and Functional Regeneration

January 2020 in “ Biomaterials Science ”

Jingjing Yuan, Qi Hou, Lingzhi Zhong, Xin Dai, Qiang Lu, Meirong Li, Xiaobing Fu

GSK-3 inhibitor SB216763 silk fibroin nanofibers chitosan wound healing skin regeneration hair follicle neogenesis ß-catenin expression Glycogen synthase kinase-3 inhibitor silk protein fibers hair follicle formation beta-catenin expression

Studysummary In this study, small molecule-loaded silk fibroin nanofiber scaffolds with chitosan achieved sustained release of GSK-3 inhibitor SB216763, leading to enhanced wound healing and hair follicle neogenesis in skin regeneration efforts.

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