Sustained Release of Inhibitor from Bionic Scaffolds for Wound Healing and Functional Regeneration

    January 2020 in “ Biomaterials Science ”
    Jingjing Yuan, Qi Hou, Lingzhi Zhong … Xiaobing Fu
    Studysummary In this study, small molecule-loaded silk fibroin nanofiber scaffolds with chitosan achieved sustained release of GSK-3 inhibitor SB216763, leading to enhanced wound healing and hair follicle neogenesis in skin regeneration efforts.
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    Research cited in this study 11

    1. Pre-Aggregation of Scalp Progenitor Dermal and Epidermal Stem Cells Activates the WNT Pathway and Promotes Hair Follicle Formation In Vitro and In Vivo Systems Stem Cell Research & Therapy · 2019
    2. Chitosan/LiCl Composite Scaffolds Promote Skin Regeneration in Full-Thickness Loss Science China Life Sciences · 2019
    3. Scarless Wound Healing: Finding the Right Cells and Signals Cell and Tissue Research · 2016
    4. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    5. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    6. The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons Cell · 2011
    7. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    8. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    9. Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing BMC Cell Biology · 2006
    10. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    11. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002