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    GlossaryRegenerative Potential

    ability to repair or regrow damaged cells or tissues

    Regenerative potential refers to the ability of cells, tissues, or organs to repair or regrow after damage. In the context of hair and alopecia, it indicates the capacity of hair follicles to regenerate and produce new hair, which is crucial for developing treatments for hair loss conditions. This concept is significant in both medical research and clinical applications, as it underpins the development of therapies aimed at restoring normal function and appearance.

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      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

      learn SCUBE3

      a signaling molecule from dermal papilla cells being actively researched

      learn Verteporfin

      chemical that might completely regrow follicles from hair transplant extractions

      learn Valproic acid

      an anticonvulsant repurposed for hair loss via histone inhibition

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      community PP405 Phase 2a press release with early results

      in Research/Science  689 upvotes 3 weeks ago
      PP405 shows promise in hair regrowth, with 31% of participants experiencing over 20% increase in hair density after 8 weeks. Phase 3 trials are expected in 2026, with potential market availability by 2029-2031.

      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Why only the top of the head?!

      in Chat 2 years ago
      Why the top of the head is affected by hair loss more than other areas, and treatments such as surgery, medications like minoxidil, finasteride, and RU58841 to treat it.

      community Dr. Bloxham's Verteporfin Trial

      in Research/Science  31 upvotes 1 year ago
      Dr. Bloxham's trial is testing verteporfin on hair transplant patients to see if it can improve hair regrowth in treated areas. People are discussing the potential for follicle regeneration, expected results timeline, and concerns about side effects like cancer.