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    GlossaryRegenerative Capacity

    ability to repair or regrow damaged cells and tissues

    Regenerative capacity refers to the ability of an organism or tissue to repair or replace damaged cells and tissues. In the context of hair, it involves the hair follicles' ability to regrow hair after it has been lost due to injury, disease, or other factors. This capacity varies among different tissues and organisms, with some having a high regenerative potential, like liver tissue, while others, like certain types of nerve cells, have limited ability to regenerate.

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      learn Valproic acid

      an anticonvulsant repurposed for hair loss via histone inhibition

      learn Microneedling

      technique to create small wounds in skin to activate collagen production and hair growth
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      learn Platelet-Rich Plasma

      growth factors taken from your blood and injected into your scalp to stimulate hair

      learn SCUBE3

      a signaling molecule from dermal papilla cells being actively researched

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      community Verteporfin and Microneedling

      in Treatments 7 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.
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      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  828 upvotes 5 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.