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Glossarytransdifferentiation

mature cell changes directly into another mature cell type

Transdifferentiation is a biological process where one type of mature cell transforms into another type of mature cell without first reverting to a stem cell state. For example, a skin cell might change directly into a nerve cell. This process is significant in regenerative medicine and tissue engineering because it offers potential for repairing damaged tissues and organs.

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research Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals

130 citations , February 2005 in “Proceedings of the National Academy of Sciences”

Corneal cells can transform into skin and hair cells through specific signals.

research Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis.

55 citations , January 2004 in “The International Journal of Developmental Biology”

Corneal cells can transform into hair-producing skin cells when exposed to certain signals.

research Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4

15 citations , January 2015 in “Stem cells international”

Human hair follicle stem cells can be turned into red blood cells.

research Transdifferentiation of rat hair follicle stem cells to epithelium-like cells induced by stroma of limbus corneae

January 2008 in “Di-san junyi daxue xuebao”

Rat hair follicle stem cells can become corneal epithelium-like cells when exposed to rabbit corneal limbal stroma.

research Retinoic Acid-Induced Epidermal Transdifferentiation in Skin

1 citations , June 2014 in “Journal of developmental biology”

Retinoic acid helps change skin cells and is important for skin development and hair growth.

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