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    Glossary transdifferentiation

    mature cell changes directly into another mature cell type

    Transdifferentiation is a biological process where one type of mature cell transforms into another type of mature cell without first reverting to a stem cell state. For example, a skin cell might change directly into a nerve cell. This process is significant in regenerative medicine and tissue engineering because it offers potential for repairing damaged tissues and organs.

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    Research 30 of 444

    1. Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals Proceedings of the National Academy of Sciences · 2005 · 130 citations
    2. Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis. The International Journal of Developmental Biology · 2004 · 55 citations
    3. Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4 Stem cells international · 2015 · 15 citations
    4. Transdifferentiation of rat hair follicle stem cells to epithelium-like cells induced by stroma of limbus corneae Di-san junyi daxue xuebao · 2008
    5. Phloem transdifferentiation from immature xylem cells during bark regeneration after girdling in Eucommia ulmoides Oliv Journal of Experimental Botany · 2008 · 44 citations
    6. Retinoic Acid-Induced Epidermal Transdifferentiation in Skin Journal of developmental biology · 2014 · 1 citations
    7. P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression Stem Cell Research & Therapy · 2016 · 24 citations
    8. Corneal epithelial‐like transdifferentiation of hair follicle stem cells is mediated by pax6 and β‐catenin/Lef‐1 Cell Biology International · 2009 · 20 citations
    9. Transcription factor-based transdifferentiation of human embryonic to trophoblast stem cells Development · 2024 · 4 citations
    10. Limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial‐like cells Acta Ophthalmologica · 2008
    11. Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells into Corneal Epithelial-like Cells Stem Cells · 2008 · 162 citations
    12. Immunophenotypical analyses of myofibroblasts in rat excisional wound healing: possible transdifferentiation of blood vessel pericytes and perifollicular dermal sheath cells into myofibroblasts. PubMed · 2012 · 26 citations
    13. Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic acid-induced transdifferentiation from epidermis to mucosal epithelium The International Journal of Developmental Biology · 2011 · 14 citations
    14. Gingerol ameliorates chronic graft-versus-host disease by regulating treg/Th17 transdifferenciation Blood · 2025
    15. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes Development · 2017 · 160 citations
    16. Signaling in the stem cell niche: regulating cell fate, function and plasticity Development · 2018 · 139 citations
    17. Wound Healing: A Paradigm for Regeneration Mayo Clinic Proceedings · 2013 · 64 citations
    18. Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform? Stem Cells International · 2015 · 40 citations
    19. Epidermal stem cells: an update on their potential in regenerative medicine Expert opinion on biological therapy · 2013 · 9 citations
    20. Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis Frontiers in Cell and Developmental Biology · 2025
    21. 3D Co-Culture model of Endothelial Colony Forming Cells (ECFCs) Reverses Late Passage Adipose-derived Stem Cell Senescence for Wound Healing Research Square (Research Square) · 2020
    22. Cellular Plasticity in Cutaneous Wound Healing Biomedical Journal of Scientific & Technical Research · 2018
    23. Label Retaining Cells (LRCs) with Myoepithelial Characteristic from the Proximal Acinar Region Define Stem Cells in the Sweat Gland PLoS ONE · 2013 · 36 citations
    24. Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ iScience · 2020 · 22 citations
    25. Intravital imaging of hair-cell development and regeneration in the zebrafish Frontiers in Neuroanatomy · 2013 · 19 citations
    26. <i>In vivo</i> imaging of mammary epithelial cell dynamics in response to lineage-biased Wnt/β-catenin activation bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 1 citations
    27. Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis Development · 2003 · 421 citations
    28. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004 · 131 citations
    29. Small molecules and small molecule drugs in regenerative medicine Drug Discovery Today · 2013 · 51 citations
    30. Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid ˜The œAmerican journal of pathology · 2010 · 19 citations