Insight Into Reepithelialization: How Do Mesenchymal Stem Cells Perform?

The document from 2016 reviews the role of mesenchymal stem cells (MSCs) in the process of reepithelialization, which is essential for wound healing. MSCs are shown to enhance this process by modulating inflammation, secreting growth factors, differentiating into skin cells, and recruiting other cells to the wound site, which is particularly beneficial for chronic wounds and hypertrophic scars. The review indicates that MSCs can reduce inflammation, promote angiogenesis, and support keratinocyte migration, thus accelerating wound healing. Clinical applications of MSCs have shown promise in improving wound reepithelialization. However, the review also points out that further research is needed to fully understand MSCs' transdifferentiation mechanisms and optimize their function and delivery for therapeutic use. The potential of MSCs as seed cells for tissue-engineered skin is also discussed, supported by their pluripotency and low immunogenicity, with clinical trials demonstrating their efficacy in promoting skin healing.