Studysummary This review discusses the roles that mesenchymal stem cells may play in reepithelialization of wounds, but reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.
The document from 2016 reviews the role of mesenchymal stem cells (MSCs) in the process of reepithelialization, which is essential for wound healing. MSCs are shown to enhance this process by modulating inflammation, secreting growth factors, differentiating into skin cells, and recruiting other cells to the wound site, which is particularly beneficial for chronic wounds and hypertrophic scars. The review indicates that MSCs can reduce inflammation, promote angiogenesis, and support keratinocyte migration, thus accelerating wound healing. Clinical applications of MSCs have shown promise in improving wound reepithelialization. However, the review also points out that further research is needed to fully understand MSCs' transdifferentiation mechanisms and optimize their function and delivery for therapeutic use. The potential of MSCs as seed cells for tissue-engineered skin is also discussed, supported by their pluripotency and low immunogenicity, with clinical trials demonstrating their efficacy in promoting skin healing.
87 citations
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September 2014 in “International Journal of Molecular Sciences” This study found that the transcription factor FOXO1 plays a crucial role in wound healing by protecting keratinocytes from oxidative stress and regulating TGF-β expression.
106 citations
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March 2014 in “BioEssays” This review examines current knowledge on human epithelial hair follicle stem cells, their markers, and outlines challenges in translating findings from murine studies to human research, but does not report new experimental results.
84 citations
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August 2013 in “Journal of Cellular Biochemistry” This study found that stem cells from the human umbilical cord's Wharton's jelly may significantly enhance healing in excisional and diabetic wounds compared to controls.
156 citations
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October 2012 in “Seminars in Cell & Developmental Biology” This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.
222 citations
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August 2009 in “Experimental Dermatology” This review discusses the role of stem cells in cutaneous wound healing and reports no clinical results; the authors highlight the need for better understanding of underlying mechanisms for future therapies.
170 citations
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November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that in the absence of hair follicles, cutaneous wounds in mice showed delayed reepithelialization but eventually achieved normal wound closure after expanding the activated epidermis region.
201 citations
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August 2006 in “Cell and Tissue Research” 1279 citations
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November 2005 in “Nature Medicine”
