TLDR Mesenchymal stem cells help improve wound healing by reducing inflammation and promoting skin cell growth and movement.
The document from 2016 reviews the role of mesenchymal stem cells (MSCs) in the process of reepithelialization, which is essential for wound healing. MSCs are shown to enhance this process by modulating inflammation, secreting growth factors, differentiating into skin cells, and recruiting other cells to the wound site, which is particularly beneficial for chronic wounds and hypertrophic scars. The review indicates that MSCs can reduce inflammation, promote angiogenesis, and support keratinocyte migration, thus accelerating wound healing. Clinical applications of MSCs have shown promise in improving wound reepithelialization. However, the review also points out that further research is needed to fully understand MSCs' transdifferentiation mechanisms and optimize their function and delivery for therapeutic use. The potential of MSCs as seed cells for tissue-engineered skin is also discussed, supported by their pluripotency and low immunogenicity, with clinical trials demonstrating their efficacy in promoting skin healing.
87 citations,
September 2014 in “International Journal of Molecular Sciences” FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.
106 citations,
March 2014 in “BioEssays” We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.
156 citations,
October 2012 in “Seminars in Cell & Developmental Biology” Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.
222 citations,
August 2009 in “Experimental Dermatology” Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.
170 citations,
November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.
359 citations,
January 2015 in “Cold Spring Harbor Perspectives in Medicine” Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
222 citations,
August 2009 in “Experimental Dermatology” Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.
