FOXO1, TGF-β Regulation and Wound Healing

    September 2014 in “ International Journal of Molecular Sciences ”
    Alhassan Hameedaldeen, Jian Liu, Angelika Batres, Gabrielle Graves, Dana T. Graves
    Image of study
    TLDR FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.
    The 2014 review discusses the transcription factor FOXO1 and its significant role in wound healing. FOXO1 is essential for reducing oxidative damage, increasing TGF-β1 expression, and promoting keratinocyte migration and proliferation, which are all critical for successful wound repair. Lack of FOXO1 leads to increased oxidative damage, reduced TGF-β1 expression, and impaired re-epithelialization due to decreased keratinocyte migration and increased apoptosis. The review also addresses the altered function of FOXO1 in diabetic conditions, which results in impaired wound healing due to increased apoptosis and inflammation. High glucose levels further impair FOXO1's ability to stimulate TGF-β1, exacerbating poor healing outcomes. The document suggests that while FOXO1 is crucial for normal wound healing, its dysregulation in diabetes can hinder the healing process, making it a potential therapeutic target for improving wound repair in diabetic patients.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 6 results

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  6 upvotes 7 months ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

      community Stop expecting results in 2 months!

      in Treatment  125 upvotes 7 months ago
      People discussing hair loss treatments emphasize the need for patience, as results from using finasteride and minoxidil can take 8-12 months or longer. Some users report early signs of improvement, while others experience continued shedding or slower progress.

      community Massive hair gains! Hope! May this post be a light to you in dark phases when all other lights go out

      in Progress Pictures  193 upvotes 7 months ago
      A 27-year-old man saw significant hair regrowth after starting a regimen in January that included topical minoxidil with finasteride, vitamins D and B12, fish oil, zinc with magnesium, quitting smoking, and intermittent fasting. People commented on the effectiveness of minoxidil in Southern populations and asked about the details and timeline of his treatment.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  142 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Kintor Phase 2 Results released KX-826 (pyrilutamide)

      in Research/Science  451 upvotes 2 years ago
      Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.

    Similar Research

    5 / 713 results