Retinoic Acid-Induced Epidermal Transdifferentiation in Skin

June 2014 in “ Journal of developmental biology ”

Yoshihiro Akimoto, Mary Miyaji, Riyo Morimoto-Kamata, Yasuhiro Kosaka, Akiko Obinata

retinoic acid epidermal transdifferentiation embryonic skin epithelial-mesenchymal interactions Gbx1 Tgm2 TGF-β2 hair follicle formation Wnt/β-catenin pathway transcription factors skin morphogenesis skin differentiation therapeutic applications hair loss RA skin transformation skin development skin therapy

Studysummary This study found that retinoic acid induces epidermal transdifferentiation into mucosal epithelium in both chick and mammalian embryonic skin, involving specific gene expressions and pathways. Our plain-language summary of this paper — not a Tressless recommendation.

The document reviewed the role of retinoic acid (RA) in inducing epidermal transdifferentiation in embryonic skin, highlighting its ability to transform epidermal cells into mucosal epithelium through epithelial-mesenchymal interactions. Key molecular players included Gbx1, Tgm2, and TGF-β2. RA influenced hair follicle formation and barrier formation by affecting the Wnt/β-catenin pathway and various transcription factors. The study underscored RA's importance in skin morphogenesis and differentiation, providing insights into its broader regulatory roles and potential therapeutic applications for skin diseases and hair loss.

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research Retinoic Acid and Mouse Skin Morphogenesis: Role of Epidermal Competence in Hair Glandular Metaplasia

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