Retinoic Acid-Induced Epidermal Transdifferentiation in Skin

    June 2014 in “ Journal of developmental biology ”
    Yoshihiro Akimoto, Mary Miyaji, Riyo Morimoto-Kamata, Yasuhiro Kosaka, Akiko Obinata
    TLDR Retinoic acid helps change skin cells and is important for skin development and hair growth.
    The document reviewed the role of retinoic acid (RA) in inducing epidermal transdifferentiation in embryonic skin, highlighting its ability to transform epidermal cells into mucosal epithelium through epithelial-mesenchymal interactions. Key molecular players included Gbx1, Tgm2, and TGF-β2. RA influenced hair follicle formation and barrier formation by affecting the Wnt/β-catenin pathway and various transcription factors. The study underscored RA's importance in skin morphogenesis and differentiation, providing insights into its broader regulatory roles and potential therapeutic applications for skin diseases and hair loss.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 100 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community How important are Retinoic and Hydrocortisone in topical serum?

      in Treatment  4 upvotes 2 weeks ago
      The conversation is about using a topical serum for hair loss with ingredients like finasteride and minoxidil, and the option to exclude retinoic acid and hydrocortisone due to concerns about long-term effects. One user prefers using only finasteride, avoiding minoxidil and retinoic acid, and plans to remove hydrocortisone in future orders.

      community Does anybody else got their hair ruined when on tretinoin?

      in Chat  4 upvotes 6 months ago
      The user experienced hair shedding and follicle shrinkage when using retinoic acid, despite trying different concentrations and frequencies. The hair loss persisted for six months but regrew after stopping the treatment.

    Similar Research

    5 / 1000+ results