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Glossary Epidermal Differentiation

process where skin cells mature to form protective barrier

Epidermal differentiation is the process by which cells in the outermost layer of the skin, called the epidermis, mature and change to form a protective barrier. This involves the transformation of basal cells into specialized cells like keratinocytes, which produce keratin, a protein that helps protect the skin from environmental damage. This process is crucial for maintaining skin integrity and function.

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Research

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research Retinoic Acid-Induced Epidermal Transdifferentiation in Skin

1 citations , June 2014 in “Journal of developmental biology”

This study found that retinoic acid induces epidermal transdifferentiation into mucosal epithelium in both chick and mammalian embryonic skin, involving specific gene expressions and pathways.

research Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals

130 citations , February 2005 in “Proceedings of the National Academy of Sciences”

This study found that differentiated cells of the corneal epithelium can be converted to hair and interfollicular epidermis through a multistep process involving dermal developmental signals.

research Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis.

55 citations , January 2004 in “The International Journal of Developmental Biology”

This study reports that corneal transient amplifying cells can be reprogrammed into epidermal cells capable of forming hair follicles in response to embryonic dermis signals.

research P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression

24 citations , December 2016 in “Stem Cell Research & Therapy”

This study found that P311 triggers transdifferentiation of epidermal stem cells into myofibroblast-like cells via TGFβ1/Smad signaling during wound healing.

research Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic acid-induced transdifferentiation from epidermis to mucosal epithelium

14 citations , January 2011 in “The International Journal of Developmental Biology”

This study showed that coexpression of TG2 and Gbx1 in the epidermis is necessary for esophagus-like mucosal transdifferentiation, with TGF-beta2 in the dermis essential for the process through epithelial-mesenchymal interaction.

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learn Epidermal Growth Factor

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community Does applying Epidermal Growth Factor (EGF) make a difference in hair growth?

4 upvotes 3 years ago

Applying Epidermal Growth Factor (EGF) topically may improve skin and potentially promote scalp health and hair growth, especially after microneedling. The user shares their positive experience with EGF and provides a product link.

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