Effects of In Utero Retinoic Acid Exposure on Mouse Pelage Hair Follicle Development

    June 2002 in “ Veterinary Dermatology ”
    Rosa A. García‐Fernández, Claudia Pérez‐Martínez, A. Escudero-Díez, María José García Iglesias
    TLDR Prenatal retinoic acid exposure increased cell proliferation in mouse hair follicles without affecting their development.
    The study investigated the effects of prenatal exposure to all-trans-retinoic acid (RA) on mouse pelage hair follicle development. Pregnant mice were given a single oral dose of RA at 30 mg/kg body weight on day 11.5 of gestation. The results showed no RA-induced changes in the morphology or temporal expression patterns of keratins during hair follicle morphogenesis. However, there was a significant increase in the number of BrdU-positive nuclei in hair bulbs from RA-exposed fetuses compared to non-exposed mice. The absence of adverse effects from RA suggests that this experimental design could be useful for studying the in vivo effects of retinoids on various skin diseases.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 176 results

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  739 upvotes 3 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 1 year ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community Painkillers May Block Minoxidil

      in Research/Science  14 upvotes 11 months ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community Dutasteride for trans men? (Topical vs oral?)

      in Transgender 1 year ago
      The conversation discusses using dutasteride, both topical and oral, for hair loss in trans men, considering potential side effects like depression and libido issues. The user is exploring options including topical solutions with minoxidil, retinoic acid, and hydrocortisone, and plans to start microneedling.

      community To all my thinning homies - use hair dye!!

      in Styling  51 upvotes 2 years ago
      The conclusion of the conversation is that dying the hair can be an effective method for managing hair loss, particularly for those with diffuse thinning.

    Related Research

    5 / 5 results