TLDR Dermal-epidermal interactions are crucial for hair growth and maintenance.
The document discussed the critical role of dermal-epidermal interactions in both the development and maintenance of hair follicles, emphasizing the well-established inductive properties of dermal papillae from adult vibrissa follicles. It highlighted the lesser-known effects of adult follicle epidermis on dermal cells and the inductive properties of papilla cells from other follicle types. Cultured papilla cells were noted for their ability to support the proliferation of skin epidermal cells, although they did not induce more complex organization or differentiation. However, germinative epidermal cells from the follicle base were distinct in their morphology and behavior, and when associated with papilla cells, they formed complex structures with a distinct basal lamina.
39 citations,
April 1992 in “Development” Both cell and non-cell parts are important for rat whisker follicle regrowth.
45 citations,
December 1991 in “Annals of the New York Academy of Sciences” ECM molecules are crucial for hair growth and development.
44 citations,
December 1991 in “Annals of the New York Academy of Sciences” EGF and FGF help hair growth by affecting cell differentiation and fiber growth.
68 citations,
December 1991 in “Annals of the New York Academy of Sciences” Hair growth can be induced by certain cells found at the base of hair follicles, and these cells may also influence hair development and regeneration.
131 citations,
July 2009 in “Experimental Dermatology” The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.
5 citations,
January 2016 in “Journal of Molecular Histology” Both main and alternative Wnt signaling are important for regrowing rodent whisker follicles.
321 citations,
December 2009 in “Journal of Dermatological Science” Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
11 citations,
October 2001 in “Tissue engineering” Cultured epithelium can form hair follicles when combined with dermal papillae.
