Dermal-Epidermal Interactions: Follicle-Derived Cell Populations in the Study of Hair-Growth Mechanisms
TLDR Dermal-epidermal interactions are crucial for hair growth and maintenance.
The document discussed the critical role of dermal-epidermal interactions in both the development and maintenance of hair follicles, emphasizing the well-established inductive properties of dermal papillae from adult vibrissa follicles. It highlighted the lesser-known effects of adult follicle epidermis on dermal cells and the inductive properties of papilla cells from other follicle types. Cultured papilla cells were noted for their ability to support the proliferation of skin epidermal cells, although they did not induce more complex organization or differentiation. However, germinative epidermal cells from the follicle base were distinct in their morphology and behavior, and when associated with papilla cells, they formed complex structures with a distinct basal lamina.
