Epidermal Stem Cells: An Update on Their Potential in Regenerative Medicine
March 2013
in “
Expert opinion on biological therapy
”
TLDR Epidermal stem cells have potential for personalized regenerative medicine but need careful handling to avoid cancer.
The document discussed the crucial role of adult epidermal stem cells in skin tissue regeneration and highlighted recent findings on their properties, functions, and potential in regenerative medicine. It noted that keratinocytes might have a transcriptional profile favorable for reprogramming, suggesting new strategies for patient-specific cell therapies. The paper provided an overview of the cells' differentiation and transdifferentiation capacities and their potential for tumorigenesis. The expert opinion emphasized the need for developing effective methods for lineage conversion between cell types and tailoring treatments to individual patients while minimizing cancer risks.
