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research Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that the deletion of Med1 in dental epithelia causes a shift from dental to hair tissue development, suggesting the importance of Med1 in maintaining tissue-specific lineage.

research Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics

1 citations , July 2023 in “Communications biology”

In this study, researchers found that deleting Med1, a key epigenetic regulator in dental epithelia, led to hair growth on mouse incisors by altering enhancer landscapes and causing a switch from dental to hair lineage transcription programs.

research Defining the transcriptional signature of esophageal-to-skin lineage conversion

3 citations , February 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that exposing adult esophageal epithelial cells to skin stroma can induce them to transition toward a hair follicle identity, with HIF1a playing a crucial role in this conversion process.

research Author response: Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

1 citations , May 2020

This study found that a combination of four transcription factors can transform mouse fibroblasts into cells resembling inner ear hair cells, potentially aiding research into hearing loss treatments.

research Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors

66 citations , December 2014 in “Nature Communications”

Fibroblasts can be turned into melanocytes for potential skin treatments.

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5 / 18 results

community What about cofactor NADPH ? Why don't we ever talk about it ?

11 upvotes 2 years ago

The conversation discusses the role of NADPH in hair loss and the potential impact of creatine and B complex vitamins on hair shedding. The user theorizes that increasing NAD levels with B complex vitamins may reduce hair shedding, despite using finasteride and minoxidil for 9 months.

community Is anyone taking creatine while on fin and/or dut?

in Finasteride/Dutasteride 33 upvotes 2 years ago

The conversation discusses the use of creatine while on finasteride and/or dutasteride for hair loss. Opinions vary, with some users reporting no issues and others experiencing accelerated hair loss, suggesting effects are individual.

community Does whey protein and creatine aggravate hair loss?

79 upvotes 2 years ago

The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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