Ultrasound-Activated Piezoelectric Hydrogel Scaffold for Synergistic Immunomodulation and Angiogenesis in Accelerated Wound Healing

    August 2025 in “ Acta Biomaterialia ”
    Pengfei Yan, Hui Zheng, Peng Liu … Swee Hin Teoh
    Studysummary This study presents a novel hydrogel scaffold made from tilapia collagen, which when activated by ultrasound, reprograms macrophages to promote wound healing, enhance angiogenesis, and stimulate hair follicle regeneration, offering a potential new method for treating inflammatory wounds.
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    Research cited in this study 6

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    2. Human Fibroblast-Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through Interactions With Macrophages Advanced science · 2024
    3. All-Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity Advanced Science · 2023
    4. Electrical Stimulation to Human Dermal Papilla Cells for Hair Regenerative Medicine Journal of Bioscience and Bioengineering · 2022
    5. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    6. Regeneration of Skin Appendages and Nerves: Current Status and Further Challenges Journal of Translational Medicine · 2020