Ultrasound-Activated Piezoelectric Hydrogel Scaffold for Synergistic Immunomodulation and Angiogenesis in Accelerated Wound Healing

August 2025 in “ Acta Biomaterialia ”

Pengfei Yan, Hui Zheng, Peng Liu, Chang Wang Yan, Mengqi Zhao, Sida Ling, Zuyong Wang, Chixuan Liu, Shi Hua Tan, Kun Liang, Swee Hin Teoh

ultrasound-activated piezoelectric hydrogel tilapia collagen oxidized gellan gum amino-modified barium titanate nanoparticles PI3K/Akt pathway TNF pathway macrophages angiogenesis collagen deposition hair follicle regeneration

Studysummary This study presents a novel hydrogel scaffold made from tilapia collagen, which when activated by ultrasound, reprograms macrophages to promote wound healing, enhance angiogenesis, and stimulate hair follicle regeneration, offering a potential new method for treating inflammatory wounds.

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