Human Fibroblast-Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through Interactions With Macrophages
March 2024
in “
Advanced science
”
human fibroblast-derived matrix extracellular matrix hydrogel FDM-gel collagen hydrogel hair follicle formation β-catenin pro-inflammatory cytokines M2-like macrophages VEGF bFGF integrins α5β1 integrins α1β1 Akt phosphorylation matrix metalloproteinase-9 collagen gel hair follicle beta-catenin vascular endothelial growth factor basic fibroblast growth factor integrins MMP-9
Studysummary This study observed that a novel extracellular matrix hydrogel made from human fibroblast-derived matrix improved wound healing in animal models, showing significant effects such as hair follicle formation, reduced inflammation, enhanced pro-healing growth factor levels, and interaction with macrophages, compared to traditional collagen hydrogels.
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