Human Fibroblast-Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through Interactions With Macrophages

    March 2024 in “ Advanced science ”
    Cininta Savitri, Sang Su Ha, Jae Won Kwon, Sung Hoon Kim, Young‐Min Kim, Hyun Mee Park, Hyun Joo Kwon, Mi Jung Ji, Kwideok Park
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    TLDR A new hydrogel made from human cells improves wound healing by working with immune cells to promote repair.
    The study demonstrates that Human Fibroblast-Derived Matrix (FDM) hydrogel significantly accelerates wound healing and promotes hair follicle formation by interacting with macrophages. FDM-gel enhances wound closure, dermal regeneration, collagen deposition, and neovascularization while reducing inflammation and myofibroblast presence. Mechanistic studies revealed that macrophage interactions with FDM-gel via integrins α5β1 and α1β1 increase VEGF and bFGF production, crucial for tissue regeneration. Blocking these interactions or depleting macrophages impaired healing, highlighting FDM-gel's potential as an immunomodulatory material for regenerative wound remodeling. In vivo experiments with BALB/c mice confirmed these findings, showing significant improvements in wound healing and regenerative outcomes with FDM-gel treatment.
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