Concise Review: Translating Regenerative Biology Into Clinically Relevant Therapies: Are We on the Right Path?

The review from 2017 discussed the challenges and potential of translating regenerative biology into clinically relevant therapies, focusing on the ability of certain mammals to regenerate complex tissues. It highlighted the importance of understanding the mechanisms behind regenerative responses, such as inflammation, immunity, and extracellular matrix composition, to create a pro-regenerative microenvironment. The review emphasized the role of macrophages, stem cells, and signaling pathways in tissue regeneration and the need for a deeper understanding of natural regeneration processes. It concluded that future regenerative medicine should involve combinatorial therapies integrating immune modulation, scaffold design, and controlled cell cycle activation, with interdisciplinary collaboration being crucial to overcoming current limitations and advancing regenerative therapies.