Application of Extracellular Vesicles From Mesenchymal Stem Cells Promotes Hair Growth by Regulating Human Dermal Cells and Follicles

    July 2022 in “ World journal of stem cells ”
    Ramya Lakshmi Rajendran, Prakash Gangadaran, Mi Hee Kwack, Ji Min Oh, Chae Moon Hong, Young Kwan Sung, Jaetae Lee, Byeong‐Cheol Ahn
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    TLDR Using extracellular vesicles from stem cells can help hair grow by affecting scalp cells and hair follicles.
    The study investigated the effects of human mesenchymal stem cell-derived extracellular vesicles (hMSC-EVs) on hair growth. The hMSC-EVs, which had an average diameter of 168.4 ± 78.4 nm, were found to contain Wnt3a, a protein associated with hair growth, on their membranes. These vesicles promoted the proliferation of dermal papillae (DP) and outer root sheath (ORS) cells, enhanced the expression of keratin differentiation markers in ORS cells, and increased hair shaft elongation in cultured human hair follicles. The hMSC-EVs also activated the Wnt/β-catenin signaling in recipient DP cells. These findings suggest that hMSC-EVs could potentially be used as a therapeutic treatment for hair regrowth.
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