Extracellular Vesicles Including Exosomes for Hair Follicle Regeneration

    Edith Aberdam, Alizée le Riche, Sylvie Bordes … Daniel Aberdam
    Studysummary This review discusses the potential of extracellular vesicles from various sources as promising candidates for hair growth stimulation but notes that clinical trials are needed to confirm their effectiveness and safety.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on link.springer.com →
    Discuss this study in the Community →

    Research cited in this study 44

    1. Current Advances in Stem Cell-Based Therapies for Hair Regeneration European Journal of Pharmacology · 2020
    2. Macrophage-Derived Extracellular Vesicle Promotes Hair Growth Cells · 2020
    3. Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth Theranostics · 2020
    4. Stem Cell Secretome as a New Booster for Regenerative Medicine Bioscience trends · 2019
    5. Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin Stem cells · 2019
    6. The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics International Journal of Molecular Sciences · 2019
    7. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    8. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    9. Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres Experimental Dermatology · 2019
    10. Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation International journal of biological sciences · 2019
    11. Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health Frontiers in cellular and infection microbiology · 2018
    12. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    13. Skin Cell Heterogeneity in Development, Wound Healing, and Cancer Trends in cell biology · 2018
    14. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
    15. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    16. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    17. Dermal Fibroblasts in Cutaneous Development and Healing Wiley Interdisciplinary Reviews-Developmental Biology · 2017
    18. Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice Scientific Reports · 2017
    19. Getting to the Core of the Dermal Papilla Journal of Investigative Dermatology · 2017
    20. Platelet-Rich Plasma Stimulates Angiogenesis in Mice Which May Promote Hair Growth European Journal of Medical Research · 2017
    21. The Basic Mechanism of Hair Growth Stimulation by Adipose-Derived Stem Cells and Their Secretory Factors Current Stem Cell Research & Therapy · 2017
    22. Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss Current stem cell research & therapy · 2017
    23. Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells Current stem cell research & therapy · 2017
    24. Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal npj Regenerative Medicine · 2017
    25. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    26. Protective Effect of Korean Red Ginseng Against Chemotherapeutic Drug-Induced Premature Catagen Development Assessed With Human Hair Follicle Organ Culture Model Journal of Ginseng Research · 2015
    27. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015
    28. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    29. Red Ginseng Extract Promotes Hair Growth in Cultured Human Hair Follicles Journal of Medicinal Food · 2014
    30. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    31. Comparative Secretome Analysis of Human Follicular Dermal Papilla Cells and Fibroblasts Using Shotgun Proteomics BMB Reports · 2012
    32. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    33. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    34. Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect Journal of Dermatological Science · 2011
    35. Clinically Applicable Transplantation Procedure of Dermal Papilla Cells for Hair Follicle Regeneration Journal of Tissue Engineering and Regenerative Medicine · 2011
    36. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    37. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010
    38. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    39. Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin Physiological Genomics · 2004
    40. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    41. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    42. Modulation of the Differentiated Phenotype of Keratinocytes of the Hair Follicle and Epidermis Journal of Dermatological Science · 1994
    43. Soluble Factors From Human Hair Papilla Cells And Dermal Fibroblasts Dramatically Increase The Clonal Growth Of Outer Root Sheath Cells Archives of Dermatological Research · 1993
    44. Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells Annals of the New York Academy of Sciences · 1991

    Related research 4

    1. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    2. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    3. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    4. Skin and Hair: Models for Exploring Organ Regeneration Human Molecular Genetics · 2008